| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-19 | Baltimore Ravens (10-6) | 10 | Cincinnati Bengals (6-10) | 15 | - | - |
| 2010-09-19 | Tampa Bay Buccaneers (5-11) | 20 | Carolina Panthers (7-9) | 7 | - | - |
| 2010-09-19 | Buffalo Bills (6-10) | 7 | Green Bay Packers (6-9-1) | 34 | - | - |
| 2010-09-19 | Miami Dolphins (7-9) | 14 | Minnesota Vikings (8-7-1) | 10 | - | - |
| 2010-09-19 | Chicago Bears (12-4) | 27 | Dallas Cowboys (10-6) | 20 | - | - |
| 2010-09-19 | Philadelphia Eagles (9-7) | 35 | Detroit Lions (6-10) | 32 | - | - |
| 2010-09-19 | Arizona Cardinals (3-13) | 7 | Atlanta Falcons (7-9) | 41 | - | - |
| 2010-09-19 | Kansas City Chefs (12-4) | 16 | Cleveland Browns (7-8-1) | 14 | - | - |
| 2010-09-19 | Pittsburgh Steelers (9-6-1) | 19 | Tennessee Titans (9-7) | 11 | - | - |
| 2010-09-19 | Seattle Seahawks (10-6) | 14 | Denver Broncos (6-10) | 31 | - | - |
| 2010-09-19 | St. Louis Rams () | 14 | Oakland Raiders (4-12) | 16 | - | - |
| 2010-09-19 | New England Patriots (11-5) | 14 | New York Jets (4-12) | 28 | - | - |
| 2010-09-19 | Houston Texans (11-5) | 30 | Washington Commanders (7-9) | 27 | - | - |
| 2010-09-19 | Jacksonville Jaguars (5-11) | 13 | Los Angeles Chargers (12-4) | 38 | - | - |
| 2010-09-19 | New York Giants (5-11) | 14 | Indianapolis Colts (10-6) | 38 | - | - |
| 2010-09-20 | New Orleans Saints (13-3) | 25 | San Francisco 49ers (4-12) | 22 | - | - |
| Totals | 0/0 | 0/0 | ||||
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