| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-19 | Baltimore Ravens (8-9) | 10 | Cincinnati Bengals (6-11) | 15 | - | - |
| 2010-09-19 | Tampa Bay Buccaneers (8-9) | 20 | Carolina Panthers (8-9) | 7 | - | - |
| 2010-09-19 | Buffalo Bills (12-5) | 7 | Green Bay Packers (9-7-1) | 34 | - | - |
| 2010-09-19 | Miami Dolphins (7-10) | 14 | Minnesota Vikings (9-8) | 10 | - | - |
| 2010-09-19 | Chicago Bears (11-6) | 27 | Dallas Cowboys (7-9-1) | 20 | - | - |
| 2010-09-19 | Philadelphia Eagles (11-6) | 35 | Detroit Lions (9-8) | 32 | - | - |
| 2010-09-19 | Arizona Cardinals (3-14) | 7 | Atlanta Falcons (8-9) | 41 | - | - |
| 2010-09-19 | Kansas City Chefs (6-11) | 16 | Cleveland Browns (5-12) | 14 | - | - |
| 2010-09-19 | Pittsburgh Steelers (10-7) | 19 | Tennessee Titans (3-14) | 11 | - | - |
| 2010-09-19 | Seattle Seahawks (14-3) | 14 | Denver Broncos (14-3) | 31 | - | - |
| 2010-09-19 | St. Louis Rams () | 14 | Oakland Raiders () | 16 | - | - |
| 2010-09-19 | New England Patriots (14-3) | 14 | New York Jets (3-14) | 28 | - | - |
| 2010-09-19 | Houston Texans (12-5) | 30 | Washington Commanders (5-12) | 27 | - | - |
| 2010-09-19 | Jacksonville Jaguars (13-4) | 13 | Los Angeles Chargers (11-6) | 38 | - | - |
| 2010-09-19 | New York Giants (4-13) | 14 | Indianapolis Colts (8-9) | 38 | - | - |
| 2010-09-20 | New Orleans Saints (6-11) | 25 | San Francisco 49ers (12-5) | 22 | - | - |
| Totals | 0/0 | 0/0 | ||||
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