| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-26 | Buffalo Bills (11-6) | 30 | New England Patriots (10-7) | 38 | - | - |
| 2010-09-26 | Atlanta Falcons (7-10) | 27 | New Orleans Saints (9-8) | 24 | - | - |
| 2010-09-26 | Detroit Lions (3-13-1) | 10 | Minnesota Vikings (8-9) | 24 | - | - |
| 2010-09-26 | Cleveland Browns (8-9) | 17 | Baltimore Ravens (8-9) | 24 | - | - |
| 2010-09-26 | Dallas Cowboys (12-5) | 27 | Houston Texans (4-13) | 13 | - | - |
| 2010-09-26 | San Francisco 49ers (10-7) | 10 | Kansas City Chefs (12-5) | 31 | - | - |
| 2010-09-26 | Tennessee Titans (12-5) | 29 | New York Giants (4-13) | 10 | - | - |
| 2010-09-26 | Pittsburgh Steelers (9-7-1) | 38 | Tampa Bay Buccaneers (13-4) | 13 | - | - |
| 2010-09-26 | Cincinnati Bengals (10-7) | 20 | Carolina Panthers (5-12) | 7 | - | - |
| 2010-09-26 | Philadelphia Eagles (9-8) | 28 | Jacksonville Jaguars (3-14) | 3 | - | - |
| 2010-09-26 | Washington Commanders (7-10) | 16 | St. Louis Rams () | 30 | - | - |
| 2010-09-26 | Oakland Raiders () | 23 | Arizona Cardinals (11-6) | 24 | - | - |
| 2010-09-26 | Los Angeles Chargers (9-8) | 20 | Seattle Seahawks (7-10) | 27 | - | - |
| 2010-09-26 | Indianapolis Colts (9-8) | 27 | Denver Broncos (7-10) | 13 | - | - |
| 2010-09-26 | New York Jets (4-13) | 31 | Miami Dolphins (9-8) | 23 | - | - |
| 2010-09-27 | Green Bay Packers (13-4) | 17 | Chicago Bears (6-11) | 20 | - | - |
| Totals | 0/0 | 0/0 | ||||
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