| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-26 | Buffalo Bills (4-12) | 30 | New England Patriots (14-2) | 38 | Patriots | 16 |
| 2010-09-26 | Atlanta Falcons (13-3) | 27 | New Orleans Saints (11-5) | 24 | Saints | 10 |
| 2010-09-26 | Detroit Lions (6-10) | 10 | Minnesota Vikings (6-10) | 24 | Vikings | 11 |
| 2010-09-26 | Cleveland Browns (5-11) | 17 | Baltimore Ravens (12-4) | 24 | Ravens | 8 |
| 2010-09-26 | Dallas Cowboys (6-10) | 27 | Houston Texans (6-10) | 13 | Texans | 1 |
| 2010-09-26 | San Francisco 49ers (6-10) | 10 | Kansas City Chefs (10-6) | 31 | 49ers | 4 |
| 2010-09-26 | Tennessee Titans (6-10) | 29 | New York Giants (10-6) | 10 | Titans | 2 |
| 2010-09-26 | Pittsburgh Steelers (12-4) | 38 | Tampa Bay Buccaneers (10-6) | 13 | Steelers | 9 |
| 2010-09-26 | Cincinnati Bengals (4-12) | 20 | Carolina Panthers (2-14) | 7 | Bengals | 5 |
| 2010-09-26 | Philadelphia Eagles (10-6) | 28 | Jacksonville Jaguars (8-8) | 3 | Eagles | 6 |
| 2010-09-26 | Washington Commanders (6-10) | 16 | St. Louis Rams (7-9) | 30 | Rams | 13 |
| 2010-09-26 | Oakland Raiders (8-8) | 23 | Arizona Cardinals (5-11) | 24 | Cardinals | 12 |
| 2010-09-26 | Los Angeles Chargers (9-7) | 20 | Seattle Seahawks (7-9) | 27 | Seahawks | 7 |
| 2010-09-26 | Indianapolis Colts (10-6) | 27 | Denver Broncos (4-12) | 13 | Colts | 15 |
| 2010-09-26 | New York Jets (11-5) | 31 | Miami Dolphins (7-9) | 23 | Jets | 3 |
| 2010-09-27 | Green Bay Packers (10-6) | 17 | Chicago Bears (11-5) | 20 | Packers | 14 |
| Totals | 12/16 | 107/136 | ||||
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