| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-10-07 | Los Angeles Rams () | 26 | Seattle Seahawks (13-3) | 17 | - | - |
| 2021-10-10 | New York Jets (8-8) | 20 | Atlanta Falcons (4-12) | 27 | - | - |
| 2021-10-10 | Philadelphia Eagles (10-6) | 21 | Carolina Panthers (12-4) | 18 | - | - |
| 2021-10-10 | Green Bay Packers (8-7-1) | 25 | Cincinnati Bengals (11-5) | 22 | - | - |
| 2021-10-10 | New England Patriots (12-4) | 25 | Houston Texans (2-14) | 22 | - | - |
| 2021-10-10 | Tennessee Titans (7-9) | 37 | Jacksonville Jaguars (4-12) | 19 | - | - |
| 2021-10-10 | Detroit Lions (7-9) | 17 | Minnesota Vikings (5-10-1) | 19 | - | - |
| 2021-10-10 | Denver Broncos (13-3) | 19 | Pittsburgh Steelers (8-8) | 27 | - | - |
| 2021-10-10 | Miami Dolphins (8-8) | 17 | Tampa Bay Buccaneers (4-12) | 45 | - | - |
| 2021-10-10 | New Orleans Saints (11-5) | 33 | Washington Commanders (3-13) | 22 | - | - |
| 2021-10-10 | Cleveland Browns (4-12) | 42 | Los Angeles Chargers (9-7) | 47 | - | - |
| 2021-10-10 | Chicago Bears (8-8) | 20 | Las Vegas Raiders () | 9 | - | - |
| 2021-10-10 | San Francisco 49ers (12-4) | 10 | Arizona Cardinals (10-6) | 17 | - | - |
| 2021-10-10 | New York Giants (7-9) | 20 | Dallas Cowboys (8-8) | 44 | - | - |
| 2021-10-10 | Buffalo Bills (6-10) | 38 | Kansas City Chefs (11-5) | 20 | - | - |
| 2021-10-11 | Indianapolis Colts (11-5) | 25 | Baltimore Ravens (8-8) | 31 | - | - |
| Totals | 0/0 | 0/0 | ||||
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