| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-10-03 | New York Jets (3-14) | 38 | Buffalo Bills (12-5) | 14 | - | - |
| 2010-10-03 | Seattle Seahawks (14-3) | 3 | St. Louis Rams () | 20 | - | - |
| 2010-10-03 | Carolina Panthers (8-9) | 14 | New Orleans Saints (6-11) | 16 | - | - |
| 2010-10-03 | Detroit Lions (9-8) | 26 | Green Bay Packers (9-7-1) | 28 | - | - |
| 2010-10-03 | Cincinnati Bengals (6-11) | 20 | Cleveland Browns (5-12) | 23 | - | - |
| 2010-10-03 | Baltimore Ravens (8-9) | 17 | Pittsburgh Steelers (10-7) | 14 | - | - |
| 2010-10-03 | Denver Broncos (14-3) | 26 | Tennessee Titans (3-14) | 20 | - | - |
| 2010-10-03 | San Francisco 49ers (12-5) | 14 | Atlanta Falcons (8-9) | 16 | - | - |
| 2010-10-03 | Indianapolis Colts (8-9) | 28 | Jacksonville Jaguars (13-4) | 31 | - | - |
| 2010-10-03 | Houston Texans (12-5) | 31 | Oakland Raiders () | 24 | - | - |
| 2010-10-03 | Washington Commanders (5-12) | 17 | Philadelphia Eagles (11-6) | 12 | - | - |
| 2010-10-03 | Arizona Cardinals (3-14) | 10 | Los Angeles Chargers (11-6) | 41 | - | - |
| 2010-10-03 | Chicago Bears (11-6) | 3 | New York Giants (4-13) | 17 | - | - |
| 2010-10-04 | New England Patriots (14-3) | 41 | Miami Dolphins (7-10) | 14 | - | - |
| Totals | 0/0 | 0/0 | ||||
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