| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-09-16 | New York Giants (8-8) | 29 | Washington Commanders (4-12) | 30 | - | - |
| 2021-09-19 | New Orleans Saints (13-3) | 7 | Carolina Panthers (8-8) | 26 | - | - |
| 2021-09-19 | Cincinnati Bengals (10-6) | 17 | Chicago Bears (7-9) | 20 | - | - |
| 2021-09-19 | Houston Texans (9-7) | 21 | Cleveland Browns (5-11) | 31 | - | - |
| 2021-09-19 | Los Angeles Rams () | 27 | Indianapolis Colts (14-2) | 24 | - | - |
| 2021-09-19 | Denver Broncos (8-8) | 23 | Jacksonville Jaguars (7-9) | 13 | - | - |
| 2021-09-19 | Buffalo Bills (6-10) | 35 | Miami Dolphins (7-9) | 0 | - | - |
| 2021-09-19 | New England Patriots (10-6) | 25 | New York Jets (9-7) | 6 | - | - |
| 2021-09-19 | San Francisco 49ers (8-8) | 17 | Philadelphia Eagles (11-5) | 11 | - | - |
| 2021-09-19 | Las Vegas Raiders () | 26 | Pittsburgh Steelers (9-7) | 17 | - | - |
| 2021-09-19 | Minnesota Vikings (12-4) | 33 | Arizona Cardinals (10-6) | 34 | - | - |
| 2021-09-19 | Atlanta Falcons (9-7) | 25 | Tampa Bay Buccaneers (3-13) | 48 | - | - |
| 2021-09-19 | Dallas Cowboys (11-5) | 20 | Los Angeles Chargers (13-3) | 17 | - | - |
| 2021-09-19 | Tennessee Titans (8-8) | 33 | Seattle Seahawks (5-11) | 30 | - | - |
| 2021-09-19 | Kansas City Chefs (4-12) | 35 | Baltimore Ravens (9-7) | 36 | - | - |
| 2021-09-20 | Detroit Lions (2-14) | 17 | Green Bay Packers (11-5) | 35 | - | - |
| Totals | 0/0 | 0/0 | ||||
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