| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-26 | Buffalo Bills (11-6) | 30 | New England Patriots (4-13) | 38 | Patriots | 16 |
| 2010-09-26 | Atlanta Falcons (7-10) | 27 | New Orleans Saints (9-8) | 24 | Saints | 13 |
| 2010-09-26 | Detroit Lions (12-5) | 10 | Minnesota Vikings (7-10) | 24 | Vikings | 12 |
| 2010-09-26 | Cleveland Browns (11-6) | 17 | Baltimore Ravens (13-4) | 24 | Ravens | 15 |
| 2010-09-26 | Dallas Cowboys (12-5) | 27 | Houston Texans (10-7) | 13 | Texans | 6 |
| 2010-09-26 | San Francisco 49ers (12-5) | 10 | Kansas City Chefs (11-6) | 31 | 49ers | 4 |
| 2010-09-26 | Tennessee Titans (6-11) | 29 | New York Giants (6-11) | 10 | Giants | 11 |
| 2010-09-26 | Pittsburgh Steelers (10-7) | 38 | Tampa Bay Buccaneers (9-8) | 13 | Steelers | 2 |
| 2010-09-26 | Cincinnati Bengals (9-8) | 20 | Carolina Panthers (2-15) | 7 | Bengals | 3 |
| 2010-09-26 | Philadelphia Eagles (11-6) | 28 | Jacksonville Jaguars (9-8) | 3 | Eagles | 8 |
| 2010-09-26 | Washington Commanders (4-13) | 16 | St. Louis Rams () | 30 | Commanders | 10 |
| 2010-09-26 | Oakland Raiders () | 23 | Arizona Cardinals (4-13) | 24 | Cardinals | 9 |
| 2010-09-26 | Los Angeles Chargers (5-12) | 20 | Seattle Seahawks (9-8) | 27 | Chargers | 7 |
| 2010-09-26 | Indianapolis Colts (9-8) | 27 | Denver Broncos (8-9) | 13 | Colts | 14 |
| 2010-09-26 | New York Jets (7-10) | 31 | Miami Dolphins (11-6) | 23 | Dolphins | 1 |
| 2010-09-27 | Green Bay Packers (9-8) | 17 | Chicago Bears (7-10) | 20 | Packers | 5 |
| Totals | 8/16 | 79/136 | ||||
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